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There are also ethical considerations regarding the use of tranquilizers prior to showing an animal or having an animal examined before sale.

Occasionally an animal may develop the contradictory clinical signs of aggressiveness and generalized CNS stimulation after receiving acepromazine.

IS there an interaction concern between these 2 medications? Jo and I'm here to help you with your question about Boss's medications.

I'm so sorry he has anxiety issues, but glad you're looking for the information you need to medicate him safely.

While I look up the drug interaction information, can you please tell me if Boss is otherwise healthy and/or takes any other medications or supplements? Thank you for waiting while I looked up the information on both acepromazine and amitryptiline, There are no drug interactions listed between these two drugs.

Anticholinergic Agents: Increased effects; hyperthermia and ileus possible.

Monoamine Oxidase Inhibitors (including selegiline, amitraz): Potential life threatening serotonin syndrome; use together not recommended.

Quinidine: Increased risk for QTc interval prolongation and tricyclic adverse effects.

Unless otherwise noted, use together is not necessarily contraindicated, but weigh the potential risks and perform additional monitoring when appropriate.

Acetaminophen: Possible increased risk for hypothermia. Antacids: May cause reduced GI absorption of oral phenothiazines.

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